2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Chloride Channel

Chloride Channel

Cl− Channels

Chloride Channel

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Chloride channels belong to a superfamily of ion channels that permit passive passage of anions, mainly chloride, across cell membrane. Chloride channels perform important roles in the regulation of cellular excitability, in transepithelial transport, cell volume regulation, and acidification of intracellular organelles. Chloride channels represent a group of potential drug targets.

The chloride channel protein (ClC) family comprises both chloride (Cl-) channels and chloride/proton (Cl-/H+) antiporters. In prokaryotes and eukaryotes, these proteins mediate the movement of Cl- ions across the membrane. In eukaryotes, ClC proteins play a role in the stabilization of membrane potential, epithelial ion transport, hippocampal neuroprotection, cardiac pacemaker activity and vesicular acidification.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-146334
    DFBTA
    		Inhibitor 99.25%
    DFBTA is an orally active, potent and little brain penetrated ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC50 of 24 nM. DFBTA shows analgesic efficacy for inflammatory pain.
    DFBTA
  • HY-B0799
    Dihydroergotoxine mesylate
    		Modulator 99.61%
    Dihydroergotoxine mesylate (Ergoloid mesylates) is an α-adrenergic blocking agent. Dihydroergotoxine mesylate binds with high affinity to the GABAA receptor associated Cl- channel. Dihydroergotoxine mesylate also interacts with central dopaminergic and serotonergic receptors. Dihydroergotoxine mesylate displays antiproliferative, antihypertensive and neuroprotective activity.Dihydroergotoxine mesylate (Ergoloid mesylates) is an α-adrenergic blocking agent. Dihydroergotoxine mesylate binds with high affinity to the GABAA receptor associated Cl- channel. Dihydroergotoxine mesylate also interacts with central dopaminergic and serotonergic receptors. Dihydroergotoxine mesylate displays antiproliferative, antihypertensive and neuroprotective activity.
    Dihydroergotoxine mesylate
  • HY-101329
    Anthracene-9-carboxylic acid
    		Inhibitor 99.09%
    Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells.
    Anthracene-9-carboxylic acid
  • HY-154912
    PAT1inh-B01
    		Inhibitor 98.32%
    PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl-/HCO3- exchanger)-mediated anion exchange (IC50: 350 nM). PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders.
    PAT1inh-B01
  • HY-105917
    Emidurdar
    		Inhibitor 99.41%
    Endovion is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor.
    Emidurdar
  • HY-159706
    S9-A13
    		Inhibitor
    S9-A13 is a potent and selective inhibitor SLC26A9, with the IC50 of 90.9 nM, without inhibiting other members of the SLC26 family such as SLC26A3, SLC26A4, and SLC26A6. S9-A13 can inhibits SLC26A9 Cl- currents in cells that lack expression of CFTR.
    S9-A13
  • HY-B0908
    Meticrane
    		Inhibitor 98.93%
    Meticrane is a diuretic. Meticrane inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. Meticrane is used to treat essential hypertension.
    Meticrane
  • HY-18996
    Adjudin
    		Inhibitor 98.0%
    Adjudin is an extensively studied male contraceptive with a superior mitochondria-inhibitory effect. Adjudin is also a potent Cl- channel blocker.
    Adjudin
  • HY-100613
    MONNA
    		Inhibitor 99.79%
    MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with an IC50 of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
    MONNA
  • HY-W011240
    Hydroflumethiazide
    		99.38%
    Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas.
    Hydroflumethiazide
  • HY-154912A
    PAT1inh-B01 hydrochloride
    		Inhibitor 98.0%
    PAT1inh-B01 hydrocholide is a selective SLC26A6 inhibitor. PAT1inh-B01 hydrocholide inhibits PAT1 (a Cl-/HCO3- exchanger)-mediated anion exchange (IC50: 350 nM). PAT1inh-B01 hydrocholide blocks fluid absorption in small intestine. PAT1inh-B01 hydrocholide can be used for research of small intestinal hyposecretory disorders.
    PAT1inh-B01 hydrochloride
  • HY-158183
    NMD670
    		Inhibitor 99.60%
    NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC50 of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue.
    NMD670
  • HY-N2412
    Irisolidone
    		Inhibitor 99.66%
    Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade (IC50=9.8 μM).
    Irisolidone
  • HY-103370
    Talniflumate
    		Inhibitor 99.67%
    Talniflumate (BA 7602-06) is the proagent of Niflumic acid (HY-B0493), exerting its activity in the body through conversion to niflumic acid by esterase. Talniflumate is an orally active Ca2+-activated Cl- channel (CaCC) blocker. Talniflumate can be used as an analgesic and anti-inflammatory agent in cystic fibrosis mouse model of distal intestinal obstructive syndrome.
    Talniflumate
  • HY-P0173B
    Chlorotoxin TFA
    		Inhibitor 98.46%
    Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker. Anti-cancer activity.
    Chlorotoxin TFA
  • HY-163171
    ARN11391
    		99.40%
    ARN 11391 is a selective enhancer of inositol triphosphate receptor type 1 (ITPR1). ARN 11391 can be used in the study of spinocerebellar ataxia.
    ARN11391
  • HY-N2057
    Steviol
    		Inhibitor 99.85%
    Steviol is the main metabolite of steviol glycosides and an inhibitor of AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2 and CFTR. Steviol can be used in the research of polycystic kidney disease.
    Steviol
  • HY-B1371A
    Spiperone hydrochloride
    		Activator 99.10%
    Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities.
    Spiperone hydrochloride
  • HY-W040265
    Fenamic acid
    		Inhibitor 98.19%
    Fenamic acid (N-Phenylanthranilic acid, NPAA) is an orally active chloride channel blocker. Fenamic acid is the basic constituent of non-steroidal anti-inflammatory agents (NSAIA), and derives into mefenamic, tofenacin, flufenac acid and melofenac acid. Fenamic acid also acts as antibacterial and analgesic agent-.
    Fenamic acid
  • HY-137148
    DIOA
    		Antagonist 99.1%
    DIOA is a potent acid-sensitive outwardly rectifying (ASOR) anion channel antagonist.
    DIOA
Cat. No. Product Name / Synonyms Application Reactivity